Teaching

Departmental Core Theory:

BT6020: Immunology [3 credits]

The learning outcome of this course is an overview of vertebrate immune system and detailed knowledge of the essential components of the immune system

Overview of contents

Overview of Immunology; Innate and adaptive immunity; Antigen and antibody: Structure and function; Antigen-antibody interactions as tools for research; Generation of antibody diversity: Immunoglobulin genes; Presentation of antigen by major histocompatibility complex molecules, cytokines; complement; Effector mechanisms; T-cell development; B-cell development; AIDS and the immune system; Vaccines. Special topics on advances in immunology

Text Book:

● Goldsby, Kindt, and Osborne. Kuby Immunology 6th ed. Freeman, 2007.

● Roitt's Essential Immunology. 12th Edition.Peter J. Delves,Seamus J. Martin, Dennis R. Burton,Ivan M. Roitt

Reference book:

● David Male, Jonathan Brostoff, David Roth, Ivan Roitt, Immunology; Mosby Publisher, 7th ed. 2006

● Recent articles

BT7280: Pharmacology and physiology of receptors [2 credits]

The learning outcome of this course is detailed knowledge about membrane receptors in biological systems and how they have been exploited in the biological and biomedical research.

Overview of contents

Receptor classification;
Fundamental principles of pharmacology.
Pharmacodynamics; Pharmacokinetics.
Metabolism and toxicity.
Techniques used for receptor studies (ranging from old to advanced).
Protein targeting and trafficking in mammalian cells, Imaging of receptor trafficking.
Voltage gated ion channel superfamily, Ion channels as drug targets, indirect and direct assay technologies available like patch clamp techniques, SICM etc.
Channelopathies.
Heart failure overview and Principles of cardiovascular pharmacology, Beta adrenergic concept and paradox in heart failure.

Textbooks

1.Voltage gated ion channels as drug targets-David J. Triggle,Murali Gopalakrishnan,David Rampe, Wei Zheng- John Wiley & Sons-2006.

2.Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy-David E. Golan, Armen H. Tashjian, Ehrin J. Armstrong- Lippincott Williams & Wilkins-2011.

3.Signal Transduction: Principles, Pathways, and Processes. Lewis C. Cantley, Tony Hunter, Richard Sever, Jeremy Thorner. Cold Spring Harbor Laboratory Pr (31 May 2014)

4.Receptors: Models for Binding, Trafficking, and Signaling: Models for Binding, Trafficking, and Signaling.Douglas A. Lauffenburger and Jennifer Linderman. Oxford University Press (5 August 1993)

Reference book